What is a Prolactin (PRL) Test?
The Prolactin (PRL) test measures the level of the lactogenic hormone produced by your pituitary gland. While its primary role is to stimulate breast milk production after childbirth, balanced prolactin levels are essential for the reproductive health of both men and women. A Prolactin test is a vital diagnostic tool used to investigate hormonal imbalances that may interfere with ovulation in women or testosterone production in men — often serving as a key indicator of pituitary gland function.
The Importance of Prolactin Screening
Even slight elevations in prolactin (hyperprolactinemia) can have significant clinical impacts:
- Investigating Infertility — High prolactin inhibits GnRH which suppresses FSH and LH, disrupting ovulation in women and testosterone production in men
- Menstrual Irregularities — Diagnoses the cause of absent or irregular periods (amenorrhea or oligomenorrhea)
- Pituitary Health — Screens for prolactinoma, a non-cancerous tumor of the pituitary gland that is the most common cause of significantly elevated prolactin
- Investigating Galactorrhea — Evaluates unexplained nipple discharge in both men and non-lactating women
- Male Reproductive Health — Identifies the cause of low libido, erectile dysfunction, low testosterone or gynecomastia in men
Normal Prolactin Reference Ranges
| Category | Normal Prolactin Range |
|---|---|
| Non-pregnant Women | 2.8 – 29.2 ng/mL |
| Pregnant Women (1st trimester) | Up to 80 ng/mL |
| Pregnant Women (3rd trimester) | Up to 400 ng/mL |
| Breastfeeding Women | Highly variable — up to 300 ng/mL |
| Adult Men | 2.1 – 17.7 ng/mL |
| Prepubertal Children | 3.6 – 12.0 ng/mL |
Levels above 25 ng/mL in non-pregnant women or above 17.7 ng/mL in men warrant investigation. Significantly elevated levels above 200 ng/mL strongly suggest a prolactinoma.
Causes of High Prolactin (Hyperprolactinemia)
- Prolactinoma — most common cause of significantly elevated prolactin (above 100–200 ng/mL). A benign pituitary tumor that produces excess prolactin.
- Medications — antipsychotics, antidepressants, antihypertensives (metoclopramide, risperidone, methyldopa) can all raise prolactin.
- Hypothyroidism — low thyroid hormone causes TRH elevation which in turn stimulates prolactin production.
- PCOS — mildly elevated prolactin is common in PCOS.
- Stress, exercise, sleep deprivation — physiological causes of transient mild elevation.
- Chest wall stimulation or surgery — can trigger prolactin release via nerve pathways.
- Macroprolactinemia — a benign condition where large inactive prolactin molecules give falsely elevated readings.
When is a Prolactin Test Recommended?
Your doctor may recommend a Prolactin test if you experience:
- Irregular, infrequent or absent menstrual periods
- Unexplained infertility in men or women
- Nipple discharge (galactorrhea) when not pregnant or breastfeeding
- Low sex drive or erectile dysfunction in men
- Gynecomastia (breast tissue enlargement in men)
- Headaches or visual disturbances (possible pituitary tumor)
- Low testosterone in men despite normal LH and FSH
- PCOS investigation alongside LH, FSH and testosterone
- Monitoring treatment for a known prolactinoma
What Conditions Does Prolactin Help Diagnose?
- Hyperprolactinemia (elevated prolactin)
- Prolactinoma (pituitary tumor)
- Hypothyroidism (secondary cause of high prolactin)
- Anovulation and infertility
- Amenorrhea (absent periods)
- Galactorrhea (unexplained nipple discharge)
- Male hypogonadism and erectile dysfunction
- Macroprolactinemia
- Pituitary gland disorders
Prolactin Test Price in Kolkata
Early morning draw preferred (2–3 hrs after waking) | Avoid stress & exercise before test | Free home collection above ₹2,000
Tests Commonly Ordered Alongside Prolactin
- Thyroid Profile (TSH) — hypothyroidism is a common reversible cause of elevated prolactin
- LH & FSH — high prolactin suppresses these hormones; ordered together to assess the full reproductive hormone picture
- Testosterone — in men, high prolactin suppresses testosterone; ordered alongside prolactin in low-T evaluation
- Estradiol — in women, ordered alongside prolactin in infertility and menstrual irregularity workup
- AMH — if ovarian reserve needs to be assessed alongside prolactin in infertility workup
- Macroprolactin screening — if prolactin is mildly elevated without symptoms, to exclude benign macroprolactinemia
Home Collection for Prolactin Test in Kolkata
Apollo Diagnostics provides early morning home blood sample collection for Prolactin tests across North and Central Kolkata. Since prolactin is sensitive to stress and time of day, our early 7:00 AM collection slots are ideal. Samples are processed using CLIA technology at our NABL-certified central laboratory.
- Home collection available: 7:00 AM – 2:30 PM Daily
- Early morning slots from 7:00 AM ideal for prolactin testing
- Avoid stress, exercise and breast stimulation before collection
- Free home collection on orders above ₹2,000
- Digital reports delivered to WhatsApp within 24 hours
→ Apollo Diagnostics Nagerbazar → Full List of Individual Tests → Book Home Collection → Full Body Checkup Packages
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